Publikationen Annette Aichem

  • Bialas J, Boehm AN, Catone N, Aichem A, Groettrup M. 2019. The ubiquitin-like modifier FAT10 stimulates the activity of the deubiquitylating enzyme OTUB1. J Biol Chem Feb 4. pii: jbc.RA118.005406. doi: 10.1074/jbc.RA118.005406. [Epub ahead of print].
  • Aichem A, Boehm AN, Catone N, Schmidtke G, Groettrup M. 2019. Analysis of modification and proteolytic targeting by the ubiquitin-like modifier FAT10. Methods Enzymol 618:229-256. doi: 10.1016/bs.mie.2018.12.040. Epub 2019 Feb 83.
  • Aichem A, Anders S, Catone N, Rößler P, Stotz S, Berg A, Schwab R, Scheuermann S, Bialas J, Schütz-Stoffregen MC, Schmidtke G, Peter C, Groettrup M, Wiesner S. 2018. The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation. Nat Commun Aug 20;9(1):3321. doi: 10.1038/s41467-018-05776-3.
  • Schregle R, Mah MM, Mueller S, Aichem A, Basler M, Groettrup M. 2018. The expression profile of the ubiquitin-like modifier FAT10 in immune cells suggests cell type-specific functions. Immunogenetics Mar 5. doi: 10.1007/s00251-018-1055-5. [Epub ahead of print].
  • Sacristan-Reviriego A, Bellingham J, Prodromou C, Boehm AN, Aichem A, Kumaran N, Bainbridge J, Michaelides M, van der Spuy J. 2018. The integrity and organization of the human AIPL1 functional domains is critical for its role as a HSP90-dependent co-chaperone for rod PDE6. Hum Mol Genet Apr 1;27(7):1309. doi: 10.1093/hmg/ddy024.
  • Spinnenhirn V, Bitzer A, Aichem A, Groettrup M. 2016. Newly translated proteins are substrates for ubiquitin, ISG15 and FAT10. FEBS Lett. doi: 10.1002/1873-3468.12512. [Epub ahead of print].
  • Aichem A, Groettrup M. 2016. The ubiquitin-like modifier FAT10 in cancer development. Int J Biochem Cell Biol. Jul 5. pii: S1357-2725(16)30165-0. doi: 10.1016/j.biocel.2016.07.001. [Epub ahead of print]
  • Dufner A, Kisser A, Niendorf S, Basters A, Reissig S, Schönle A, Aichem A, Kurz T, Schlosser A, Yablonski D, Groettrup M, Buch T, Waisman A, Schamel WW, Prinz M, Knobeloch KP. 2015. The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells. Nature Immunol. Jul 27. doi: 10.1038/ni.3230.
  • Bialas J, Groettrup M, Aichem A. 2015. Conjugation of the Ubiquitin Activating Enzyme UBE1 with the Ubiquitin-Like Modifier FAT10 Targets It for Proteasomal Degradation. PLoS One. Mar 13;10(3):e0120329. doi: 10.1371/journal.pone.0120329. eCollection 2015.
  • Spinnenhirn V, Farhan H, Basler M, Aichem A, Canaan A, Groettrup M. 2014. The ubiquitin-like modifier FAT10 decorates autophagy targeted Salmonella and contributes to resistance of mice. J Cell Sci Sep 30. pii: jcs.152371. [Epub ahead of print].
  • Aichem A, Catone N, Groettrup M. 2014. Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme USE1.FEBS J doi: 10.1111/febs.12745. [Epub ahead of print].
  • Schmidtke G, Aichem A, Groettrup M. 2013. FAT10ylation as a signal for proteasomal degradation. Biochim Biophys Acta Mol Cell Res 1843(1):97-102.
  • Aichem A, Kalveram B, Spinnenhirn V, Kluge K, Catone N, Johansen T, Groettrup M. 2012. The proteomic analysis of FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation.J Cell Sci 125(19):4576-4585.
  • Aichem A, Groettrup M. 2012. Detection and analysis of FAT10 modification. Methods Mol Biol 832:125-32.
  • Rani N, Aichem A, Schmidtke G, Kreft S, Groettrup M. 2012. FAT10 and NUB1L bind the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis. Nature Comm 2012 March 20;. doi: 10.1038/ncomms1752.
  • Thiel J, Kimmig L, Salzer U, Grudzien M, Lebrecht D, Hagena T, Draeger R, Völxen N, Bergbreiter A, Jennings S, Gutenberger S, Aichem A, Illges H, Hannan JP, Kienzler AK, Rizzi M, Eibel H, Peter HH, Warnatz K, Grimbacher B, Rump JA, Schlesier M. 2011. Genetic CD21 deficiency is associated with hypogammaglobulinemia. J Allergy Clin Immunol Oct 27. [Epub ahead of print].
  • Aichem A, Pelzer C, Lukasiak S, Kalveram B, Sheppard PW, Rani N, Schmidtke G, Groettrup M. 2010. USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis. Nat Commun 1(2):1-10.
  • Hoefer MM, Aichem A, Knight AM, Illges H. 2008. Modulation of murine complement receptor type 2 (CR2/CD21) ectodomain shedding by its cytoplasmic domain. Mol Immunol 45(8):2127-2137.
  • Aichem A, Masilamani M, Illges H. 2006. Redox-regulation of CD21-shedding involves signaling via PKC and indicates the formation of a juxtamembrane stalk. J Cell Sci 119(Pt14):2892-2902.
  • Aichem A, Mutzel R. 2001. Unconventional mRNA processing in the expression of two calcineurin B isoforms in Dictyostelium. J Mol Biol 308:873-882.
  • Kessen U, Schaloske R, Aichem A, Mutzel R. 1999. Ca2+/Calmodulin-independent activation of calcineurin from Dictyostelium by unsaturated long chain fatty acids. J Biol Chem 274(53):37821-37826.
  • Sonnemann J, Aichem A, Schlatterer C. 1998. Dissection of the cAMP induced cytosolic calcium response in Dictyostelium discoideum: the role of cAMP receptor subtypes and G protein subunits. FEBS Letters 436:271-276.